Thermo Fisher Scientific CD1d Polyclonal Antibody
CD1d 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 분석에 적합. Human, Mouse, Rat에 반응하며, Affinity chromatography로 정제됨. PBS buffer(50% glycerol) 보존, -20°C 보관.
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- PA5102477
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD1D (Accession P15813), corresponding to amino acid residues A48–D98 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851879 |
Product Specific Information
Antibody detects endogenous levels of total CD1D.
Target Information
CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin-independent expression of CD1d has also been demonstrated on human intestinal epithelial cells.
CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, structurally related to MHC proteins, and forms heterodimers with beta-2-microglobulin.
CD1 proteins mediate the presentation of lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1.
CD1 family members differ in cellular localization and specificity for lipid ligands. The CD1d protein localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.
Diseases associated with CD1D include Mycobacterium malmoense infection and autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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