Thermo Fisher Scientific CD43 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. It contributes to a repulsive barrier that interferes with cellular adhesion but can also promote leukocyte aggregation. Through interaction with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic. CD43 signaling enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 induces functionally active tumor suppressor p53 protein; however, in the absence of p53 and ARF, CD43 promotes tumor proliferation and viability. CD43 serves as an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(본 항체의 항원 구조 이미지: PA5-87221_CD43_P16150-1_Rabbit.svg / PA5-87221_CD43_P16150-1_Rabbit_PDP.jpeg)