Thermo Fisher Scientific CD56/NCAM1/NKH1 (Neuronal Cell Marker) Monoclonal Antibody (NCAM/7523)
CD56/NCAM1 단클론 항체로 신경세포 및 NK/T 세포 마커 검출에 적합. Western blot과 면역조직화학(IHC)에서 사용 가능. 인간 반응성, Mouse IgG2a 형, Protein A/G 정제. 액상 형태로 4°C 보관.
- 카탈로그번호
- 4684-MSM23-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD56/NCAM1/NKH1 (Neuronal Cell Marker) Monoclonal Antibody (NCAM/7523)
Thermo Fisher Scientific CD56/NCAM1/NKH1 (Neuronal Cell Marker) Monoclonal Antibody (NCAM/7523)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NCAM/7523 |
| Immunogen | Recombinant fragment (around aa400–650) of human NCAM1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120–180 kDa.
It is found on T cells and NK cells and is involved in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated cell adhesion.
Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma.
It is also a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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