Thermo Fisher Scientific COX5A Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive test controls include: HeLa, HepG2, mouse skeletal muscle, mouse testis, mouse heart, mouse brain, rat heart, rat kidney, Jurkat.
The target is usually localized in the mitochondrion inner membrane.

Immunogen sequence:
MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE EFDARWVTYF NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN DFASTVRILE VVKDKAGPHK EIYPYVIQEL RPTLNELGIS TPEELGLDKV

Target Information

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain.
It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane.

The complex consists of 13 mitochondrial- and nuclear-encoded subunits.
Mitochondrially encoded subunits perform electron transfer and proton pumping activities, while nuclear-encoded subunits may be involved in regulation and assembly.
The COX5A gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme.
A pseudogene, COX5AP1, is located on chromosome 14q22.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.