Thermo Fisher Scientific MAPK7 Monoclonal Antibody (OTI5C7), TrueMAB
인간 MAPK7(ERK5)을 인식하는 Mouse IgG1 단클론 항체로, WB 및 ICC/IF 실험에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태이며 PBS/BSA/glycerol 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C7 |
| Immunogen | Full length human recombinant MAPK7 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development.
MAPK7 is activated by MAP2K5/MEK5 and mediates downstream signaling of multiple receptors. Upon extracellular stimulation, MAPK7 translocates to the nucleus and regulates gene expression by phosphorylating transcription factors.
Gene deletion of MAPK7 in mice leads to defective cardiovascular development and embryonic lethality, indicating its essential role in endothelial function and vascular integrity.
ERK5 is expressed in many adult tissues, including heart, placenta, lung, kidney, and skeletal muscle, but is not detectable in liver.
Four alternatively spliced transcript variants encoding two isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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