Thermo Fisher Scientific Claudin 19 Polyclonal Antibody
Claudin 19 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간 및 랫트 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CLDN19 (Accession Q8N6F1), corresponding to amino acid residues V85–T135 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850960 |
Product Specific Information
This antibody detects endogenous levels of total CLDN19.
Target Information
The product of this gene belongs to the claudin family and plays a major role in tight junction-specific obliteration of the intercellular space through calcium-independent cell-adhesion activity.
Defects in this gene cause hypomagnesemia renal with ocular involvement (HOMGO), a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria, and nephrocalcinosis, associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia, and nystagmus.
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
[Provided by RefSeq, Jun 2010]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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