Thermo Fisher Scientific Renal Cell Carcinoma (RCC, gp200) Monoclonal Antibody (PN-15)
인간 신장암(RCC, gp200) 항원을 인식하는 PN-15 클론 단일클론 항체로, IHC(P) 및 유세포분석에 사용 가능. Carbonic Anhydrase IX를 표적으로 하며, 단백질 A로 정제된 액상 형태. 연구용으로만 사용.
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Thermo Fisher Scientific Renal Cell Carcinoma (RCC, gp200) Monoclonal Antibody (PN-15)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PN-15 |
| Immunogen | Enriched cell membrane of renal cell carcinoma (RCC, gp200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human kidney tissue
- Cellular location: Membrane
Target Information
Carbonic anhydrase (CA) is an enzyme that catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues.
CA IX is one of the most inducible genes under hypoxia via HIF-1 alpha due to its stability and membrane localization. Carbonic anhydrases regulate pH in normal tissues by controlling hydrogen ion (H⁺) flux.
Blocking CA IX increases cell death under hypoxia, making CA IX a reliable histochemical marker of hypoxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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