Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), Alexa Fluor 660, eBioscience
인간 CD223(LAG-3)을 인식하는 3DS223H 단클론 항체로, Alexa Fluor 660으로 표지되어 있습니다. 유세포분석(Flow Cytometry)에 적합하며, 활성화된 T세포 및 NK세포의 LAG-3 발현 분석에 활용됩니다. 4°C 암소 보관, 동결 금지.
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Applications
Tested Application
- Flow Cytometry (Flow)
Tested Dilution
- 5 µL (0.25 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3DS223H |
| Immunogen | hCD223-FC PFA 4% |
| Conjugate | Alexa Fluor™ 660 |
| Excitation / Emission Max | 663 / 691 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896268 |
Available Conjugate Formats
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 395 / 563 / 661 / 737 / 805
- Brilliant Violet 421 / 480 / 605 / 650 / 711 / 786
- eFluor 450 / 506
- FITC
- NovaFluor Blue 510 / 660-120S
- NovaFluor Red 700
- NovaFluor Yellow 590 / 610 / 700 / 730
- PE / PE-Cyanine5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436 / 600 / 645 / 702 / 780
- Request custom conjugation
Product Specific Information
The 3DS223H monoclonal antibody recognizes human CD223, also known as Lymphocyte Activation Gene 3 (LAG-3). LAG-3 is a 70-kDa surface glycoprotein in the Ig superfamily, homologous to CD4. It binds to MHC class II with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation.
Surface expression of LAG-3 is found on activated T cells (including regulatory T cells) and NK cells. CD8⁺ T cells typically express higher levels of LAG-3 than CD4⁺ T cells. Coexpression of LAG-3 and CD49b has been proposed as a marker of Type 1 regulatory T cells (Tr1 cells).
- Recognizes a formaldehyde-fixed epitope
- Reported application: Flow cytometric analysis
- Tested on stimulated normal human peripheral blood cells
- Recommended use: 5 µL (0.25 µg) per test in 100 µL final volume
- Alexa Fluor 660 emits at 690 nm and is suitable for spectral cytometers
- Excitation: 662 nm; Emission: 690 nm; Laser: Red Laser
Target Information
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. It binds to MHC class II with higher affinity than CD4 and functions in negative regulation of T cell activation and proliferation. Expression is observed on activated T cells (including regulatory T cells) and NK cells, with higher expression in CD8⁺ T cells. Coexpression with CD49b identifies Type 1 regulatory T cells (Tr1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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