Thermo Fisher Scientific MYH9 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: U87-MG, SK-N-SH, IMR32, SK-N-AS, NT2D1, PC-3
• Predicted reactivity: Mouse (98%), Rat (97%), Xenopus laevis (92%), Dog (99%), Chicken (96%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a key component of the actin cytoskeleton involved in cellular processes such as migration, adhesion, division, and shape maintenance.
It spans over 106 kilobases and includes 41 exons, producing a 1,960-amino acid protein that forms a hexameric complex with light chains.
Mutations in MYH9 cause autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, often associated with macrothrombocytopenia, hearing loss, renal failure, and cataracts.
MYH9 also plays a vital role in hematopoiesis, maintaining hematopoietic stem and progenitor cell function; its loss leads to severe blood cell deficiencies and bone marrow failure.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.