Thermo Fisher Scientific Neurturin Polyclonal Antibody
Thermo Fisher Scientific의 Neurturin Polyclonal Antibody는 인간 Neurturin에 특이적인 염소 유래 IgG 항체입니다. Western blot, IHC, Neutralization 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (IHC) | 5–15 µg/mL |
| Neutralization (Neu) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human Neurturin (Ala96–Val197) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2605832 |
Product Specific Information
- In direct ELISAs, less than 1% cross-reactivity with recombinant mouse Neurturin is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Glial cell line-derived neurotrophic factor (GDNF) plays key roles in neuron survival and differentiation. Neurturin (NTN), a novel neurotrophic factor cloned from human and mouse, requires receptor tyrosine kinase RET and glycosylphosphatidylinositol-linked receptor NTNRα for physiological responses. NTN binds and forms a complex with GFRα-2 and RET, activating the RET receptor tyrosine kinase pathway. Both NTN and GDNF activate MAP kinase and PI3K pathways, crucial for neuronal development. Neurturin and GDNF define a new family of neurotrophic factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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