Thermo Fisher Scientific Human Chemerin Recombinant Protein, PeproTech
인체 유래 Chemerin 재조합 단백질로, E. coli에서 발현된 15.6 kDa 크기의 고순도 단백질입니다. 인간 미성숙 수지상세포의 화학유인 활성 평가용으로 사용되며, ≥98% 순도와 낮은 엔도톡신 수준을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publication
Miscellaneous PubMed (Misc)
- Refer to publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse, Zebrafish |
| Expression System | E. coli |
| Amino Acid Sequence | ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFA |
| Molecular Weight | 15.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Chemoattracts human immature dendritic cells at 1.0–100.0 ng/ml concentration range |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human Chemerin is a 15.6 kDa protein consisting of 135 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs). Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane-bound or secreted.
TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles, and endothelial cells as well as in pancreas, spleen, and intestine. TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth-suppressive effects of retinoids.
TIG2 is a secreted protein mainly expressed in epidermis, hair follicles, and endothelial cells. TIG2 is inhibited in psoriatic lesions and activated by tazarotene in skin rafts and in epidermis of psoriatic lesions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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