Thermo Fisher Scientific IL1F6 Polyclonal Antibody
IL1F6 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에서 검증됨. 인간 및 생쥐 반응성. 고순도 정제 및 안정적 PBS/glycerol 저장. 연구용으로만 사용.
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- PA5100832
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL36A (Accession Q9UHA7), corresponding to amino acid residues E89–I139 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850333 |
Product Specific Information
Antibody detects endogenous levels of total IL1F6.
Target Information
The IL-1 family consists of 11 structurally related ligands, including IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9).
IL-36α is highly expressed in psoriatic plaques and uniquely expressed by T cells, monocytes, and B cells. It is primarily found in skin and lymphoid tissues, with minor expression in fetal brain, trachea, stomach, and intestine.
IL-36α signals through IL-1Rrp2 (IL-1R6) and IL-RAcP receptors, acting as an agonist of NF-κB and MAPK pathways to induce proinflammatory cytokines and chemokines such as IL-6, IL-8, BD-2, and BD-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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