Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/2975)
RET 단백질을 인식하는 Mouse Monoclonal Antibody로, IHC(P) 및 Peptide Array에 사용 가능. 인간 시료 반응성. Protein A/G 정제, 200 µg/mL 농도. 세포막 위치 단백질 검출에 적합. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RET/2975 |
| Immunogen | Recombinant fragment (around aa 702–848) of human RET protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Colon or prostate carcinoma, human breast tissue
- Cellular Location: Membrane
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. RET transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been identified for the RET gene, and additional variants have been reported but their biological significance remains uncertain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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