Thermo Fisher Scientific Human ILP-2 Synthetic Peptide
인간 ILP-2 단백질의 N-말단 12 아미노산 서열에 해당하는 합성 펩타이드로, PA5-19999 항체의 블로킹 펩타이드로 사용 가능. 순도 높은 액상 제형으로 PBS 버퍼에 보관되며, 인간 특이적 반응성을 가짐. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 12 amino acids from the amino terminus of human ILP-2.
PEP-0121 can be used as a blocking peptide with polyclonal antibody PA5-19999.
Target Information
Apoptosis, or programmed cell death, is related to many diseases such as cancer. It is triggered by various stimuli including TNF family members and inhibited by IAP (Inhibitor of Apoptosis) proteins.
IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP, which bind to and inhibit specific proteases.
A novel member, ILP-2 (IAP-like protein-2), has high homology to ILP-1 but is encoded by a distinct gene expressed solely in human testis.
Unlike ILP-1, ILP-2 does not inhibit Fas and TNF-induced apoptosis but strongly inhibits apoptosis induced by Bax overexpression or coexpression of caspase-9 with Apaf-1.
ILP-2 interacts with processed caspase-9, suggesting that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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