Thermo Fisher Scientific DLL4 Monoclonal Antibody (2E2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
HAPGDDLRPE ALPPDALISK IAIQGSLAVG QNWLLDEQTS TLTRLRYSYR VICSDNYYGD NCSRLCKKRN DHFGHYVCQP DGNLSCLPGW TGEYCQQPI

Target Information

Delta-like ligand 4 (DLL4), also known as Delta-4, is a homologue of the Drosophila delta protein and functions as a transmembrane-bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF) as a negative feedback regulator to control angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer. Inhibition of DLL4 increases vascular proliferation but leads to defective maturation, resulting in decreased tumor growth with no apparent toxicity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.