Thermo Fisher Scientific LRRC8B Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human LRRC8B. Recombinant protein control fragment (Product #RP-91195). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LRRC8B,uniProtId:Q6P9F7-1,ncbiNodeId:9606,antigenRange:143-252,antigenLength:803,antigenImageFileName:PA5-53675_LRRC8B_Q6P9F7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53675_LRRC8B_Q6P9F7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643555

Product Specific Information

Immunogen sequence: PSTSSRLEHF VAILHKCFDS PWTTRALSET VAEQSVRPLK LSKSKILLSS SGCSADIDSG KQSLPYPQPG LESAGIESPT SSVLDKKEGE QAKAIFEKVK RFRMHVEQKD

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

Target Information

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.