Thermo Fisher Scientific ALDH3A2 Monoclonal Antibody (OTI1D1), TrueMAB

Thermo Fisher Scientific ALDH3A2 Monoclonal Antibody (OTI1D1), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze oxidation of a wide range of aliphatic and aromatic aldehydes. These enzymes play a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation.
Aldh3A2 catalyzes oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder characterized by ichthyosis, mental retardation, and spastic diplegia. The pathogenesis is thought to involve abnormal lipid accumulation, aldehyde Schiff base formation, or defective eicosanoid metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.