Thermo Fisher Scientific IL1B Monoclonal Antibody (OTI3E1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into an active 17 kDa form by caspase-1 upon inflammasome activation. IL-1β lacks a classical signal sequence and is secreted via a noncanonical pathway. It binds to IL-1RI and IL-1RII receptors, shared with IL-1α, and its activity is modulated by IL-1 Receptor Antagonist (IL-1RA). IL-1β plays a key role in innate immunity and inflammation, and elevated levels are associated with chronic inflammatory diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.