
Thermo Fisher Scientific CDK2AP1 Polyclonal Antibody
CDK2AP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. 인간 시료에 반응하며 ICC/IF 실험에 적합. 항원 친화 크로마토그래피로 정제되었고 PBS/glycerol 버퍼에 보관. 세포주기 및 에피제네틱 연구용.
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CDK2AP1. Recombinant protein control fragment (Product #RP-106793) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662025 |
Product Specific Information
Immunogen sequence:
ATSSQYRQLLS DYGPPSLGYT QGTGNSQVPQ SKYAELLAII EELGKEI
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2)-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2 and targeting CDK2 for proteolysis. It also interacts with DNA polymerase alpha/primase and mediates phosphorylation of the large p180 subunit, suggesting a regulatory role in DNA replication during S-phase.
Additionally, this protein forms part of the nucleosome remodeling and histone deacetylation (NURD) complex, which epigenetically regulates embryonic stem cell differentiation.
Thus, CDK2AP1 plays roles in both cell-cycle and epigenetic regulation.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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