Thermo Fisher Scientific CHST14 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  AYRNKFGEIRE YQQRYGAEIV RRYRAGAGPS PAGDDVTFPE FLRYLVDEDP ERMNEHWMPV YHLCQPCAVH Y

• Ortholog identity:
  Highest antigen sequence identity to the following orthologs — mouse 99%, rat 99%.

Target Information

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-O-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of β1,4-linked GalNAc that is substituted with an α-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA- sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.