Thermo Fisher Scientific IMPACT Polyclonal Antibody
IMPACT 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 Immunoprecipitation에 적합. 비결합(Unconjugated) 형태의 액상 제품으로 1 mg/mL 농도 제공. 4°C에서 보관하며, 수령일로부터 1년의 유효기간 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 270 and 320 of human imprinted and ancient homolog |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Translational regulator that ensures constant high levels of translation under various stress conditions such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment, and glucose deprivation.
Acts as a negative regulator of EIF2AK4/GCN2 kinase activity by impairing GCN1-mediated activation, thus reducing eIF-2-alpha phosphorylation and down-regulation of protein synthesis.
May regulate translation in specific neuronal cells under amino acid starvation by preventing GCN2 activation and ATF4 synthesis.
Through inhibition of EIF2AK4/GCN2, it contributes to neuronal differentiation by promoting neurite outgrowth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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