Thermo Fisher Scientific MST1R Monoclonal Antibody (OTI1D12), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

MST1R (also known as RON) is a receptor tyrosine kinase involved in cell proliferation and motility. It forms a membrane-spanning, disulfide-linked heterodimer derived from a glycosylated precursor cleaved into 35-kDa (alpha) and 150-kDa (beta) subunits. Ligand binding induces tyrosine phosphorylation of the beta chain.
Knockout studies show that MST1R/RON (-/-) mice do not survive past the periimplantation period. The MST1R/RON gene is located on chromosome 3p21, a region often deleted or mutated in small cell lung and renal carcinomas, and is implicated in epithelial cancer progression. Expression has been observed in normal human tissues such as colon, mouth, prostate, and testis, as well as in various cancers of colon, prostate, stomach, and uterus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.