Thermo Fisher Scientific Perforin Polyclonal Antibody
Recombinant Mouse Perforin-1 단백질을 면역원으로 제작된 Rabbit Polyclonal Antibody. ELISA 검증 완료. 세포독성 림프구의 Perforin 단백질 연구용. 고순도 Protein G 정제, 액상 형태로 안정적 보관 가능.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Mouse Perforin-1 protein (21–554aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2902118 |
Product Specific Information
This antibody has been tested in direct ELISA.
Target Information
Perforin is one of the major cytolytic proteins of cytolytic granules. It acts as a cytolytic mediator stored and released by cytoplasmic granules, playing a critical role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin consists of 555 amino acids with a 21 amino acid signal peptide and has a molecular weight of approximately 70–75 kDa. It forms transmembrane pores similar to complement component C9, with demonstrated homology.
Expression is restricted to killer cell lines, not detected in helper T lymphocytes or other tumor cells. Mutations in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare autosomal recessive disorder of early childhood.
Alternative splicing generates multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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