Thermo Fisher Scientific Perforin Polyclonal Antibody

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

This antibody has been tested in direct ELISA.

Target Information

Perforin is one of the major cytolytic proteins of cytolytic granules. It acts as a cytolytic mediator stored and released by cytoplasmic granules, playing a critical role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin consists of 555 amino acids with a 21 amino acid signal peptide and has a molecular weight of approximately 70–75 kDa. It forms transmembrane pores similar to complement component C9, with demonstrated homology.
Expression is restricted to killer cell lines, not detected in helper T lymphocytes or other tumor cells. Mutations in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare autosomal recessive disorder of early childhood.
Alternative splicing generates multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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