Thermo Fisher Scientific uPAR Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Product Specifications

Product Specific Information

This antibody has been tested in direct-ELISA.

Target Information

The urokinase-type plasminogen activator receptor (uPAR) regulates cell-surface plasminogen activation and plays an important role in both normal and pathological processes. The human PLAUR cDNA encodes 335 amino acids, including a signal peptide and hydrophobic C-terminal portion, producing a glycosylated ~50 kDa protein anchored to the plasma membrane via a glycosyl-phosphatidylinositol linkage.

PLAUR (UPAR) associates with the carbohydrate-binding domain of SELL on neutrophil membranes, analogous to its interaction with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent. UPAR mRNA levels correlate with the invasiveness of endometrial carcinomas, showing up to a 33-fold increase in advanced stages compared to normal tissue. UPAR protein expression is positively correlated with recurrence and mortality rates, making it a useful prognostic marker for advanced endometrial cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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