Thermo Fisher Scientific uPAR Polyclonal Antibody
Thermo Fisher Scientific uPAR Polyclonal Antibody는 인간 및 랫트 시료에 반응하며 Western blot과 direct-ELISA에 적합합니다. Recombinant Rat Urokinase plasminogen activator receptor를 면역원으로 사용한 Rabbit IgG 폴리클로날 항체입니다. 고순도 Protein G 정제, 안정적 PBS/glycerol buffer 저장으로 연구용에 최적화되어...
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Rat Urokinase plasminogen activator surface receptor protein (25–299aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C (preferred) |
| Shipping Conditions | Wet ice |
| RRID | AB_2902116 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
The urokinase-type plasminogen activator receptor (uPAR) regulates cell-surface plasminogen activation and plays an important role in both normal and pathological processes. The human PLAUR cDNA encodes 335 amino acids, including a signal peptide and hydrophobic C-terminal portion, producing a glycosylated ~50 kDa protein anchored to the plasma membrane via a glycosyl-phosphatidylinositol linkage.
PLAUR (UPAR) associates with the carbohydrate-binding domain of SELL on neutrophil membranes, analogous to its interaction with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent. UPAR mRNA levels correlate with the invasiveness of endometrial carcinomas, showing up to a 33-fold increase in advanced stages compared to normal tissue. UPAR protein expression is positively correlated with recurrence and mortality rates, making it a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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