Thermo Fisher Scientific DR4 Polyclonal Antibody
DR4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도(>95%)로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 401–450 of Human DR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803205 |
Product Specific Information
Purity is greater than 95% as determined by SDS-PAGE.
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also known as TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, a member of the TNF family. DR4, like other receptors such as Fas and TNFR1, mediates apoptosis and NF-κB activation in many cells and tissues.
Apoptosis, a programmed cell death process, is essential in normal cellular differentiation and development of multicellular organisms. It is induced by certain cytokines (TNF family: TNF, Fas ligand) interacting with their death domain-containing receptors (TNFR1, Fas receptor).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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