Thermo Fisher Scientific RIPK2 Polyclonal Antibody
RIPK2 단백질의 인산화 및 비인산화 형태를 모두 인식하는 Rabbit Polyclonal Antibody. WB 및 IHC에 적합하며, Human과 Mouse 반응성. 액상 형태로 -20°C 보관, 연구용으로 세포 활성 및 면역반응 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (IHC) | 1–4 µg/mg |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phosphopeptide corresponding to the pY474 site of human RIPK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
This antibody can recognize both the phosphorylated and unphosphorylated target.
Target Information
RIPK2 is a serine/threonine kinase involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize, and recruit RIPK2 through CARD-CARD domains. RIPK2 contributes to tyrosine phosphorylation of ARHGEF2 via Src kinase, leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes Lys-63-linked polyubiquitination by E3 ligases XIAP, BIRC2, and BIRC3. This polyubiquitination promotes recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces further Lys-63-linked polyubiquitination, activating IKBKB/IKKB. Subsequently, NF-kappaB translocates to the nucleus, activating transcription of genes related to immune response, growth control, and apoptosis protection. RIPK2 also plays a role during T-cell receptor engagement, promoting BCL10 phosphorylation and NF-kappaB activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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