Thermo Fisher Scientific ARS2 Polyclonal Antibody
ARS2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. Human 및 Mouse 시료에 반응하며, 동결건조 형태로 제공됩니다. 연구용으로만 사용되며, 장기 보관 시 -20°C에서 보관 권장.
- 카탈로그번호
- OSS00427W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human ARS2 conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage buffer | Whole serum |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse.
Specificity of this antibody: ARS2.
Target Information
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation.
Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs.
Binds capped RNAs (m7GpppG-capped RNA); however, the interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex.
Involved in cell cycle progression at S phase.
Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal by directly binding the SOX2 promoter and positively regulating its transcription.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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