Thermo Fisher Scientific TNNT1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSDTEEQEYE EEQPEEEAAE EEEEEEERPK PSRPVVPPLI PPKIPEGERV DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELVALKE RIERRRSERA EQQRFRTEKE RERQAKLAEE KMRKEEEEAK KRAEDDAKKK KVLSNMGAHF GGYLVKAEQK RGKRQTGREM KVRILSERKK PLDIDYMGEE QLREKAQELS DWIHQLESEK FDLMAKLKQQ KYEINVLYNR ISHAQKFRKG AGKGRVGGRW K

Target Information

This gene encodes a protein that is a subunit of troponin, a regulatory complex located on the thin filament of the sarcomere. The complex regulates striated muscle contraction in response to intracellular calcium concentration changes. It consists of three subunits:

• Troponin C: Binds calcium
• Troponin T: Binds tropomyosin
• Troponin I: Inhibitory subunit

This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5 (Amish nemaline myopathy), a neuromuscular disorder characterized by muscle weakness and rod-shaped inclusions in skeletal muscle fibers, typically leading to respiratory failure in infancy. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.