Thermo Fisher Scientific TNNT1 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TNNT1 (NP_003274, 1 a.a. approximately 251 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TNNT1,uniProtId:P13805-1,ncbiNodeId:9606,antigenRange:1-278,antigenLength:278,antigenImageFileName:H00007138-B01P_TNNT1_P13805-1_House_mouse.svg,antigenImageFileNamePDP:H00007138-B01P_TNNT1_P13805-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MSDTEEQEYE EEQPEEEAAE EEEEEEERPK PSRPVVPPLI PPKIPEGERV DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELVALKE RIERRRSERA EQQRFRTEKE RERQAKLAEE KMRKEEEEAK KRAEDDAKKK KVLSNMGAHF GGYLVKAEQK RGKRQTGREM KVRILSERKK PLDIDYMGEE QLREKAQELS DWIHQLESEK FDLMAKLKQQ KYEINVLYNR ISHAQKFRKG AGKGRVGGRW K

Target Information

This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.