Thermo Fisher Scientific TNNT1 Polyclonal Antibody, MaxPab
TNNT1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. Human 시료 반응성이 있으며, Affinity chromatography로 정제되었습니다. PBS(pH 7.4)에 보존되어 있으며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TNNT1 (NP_003274, 1 a.a. ~ 251 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MSDTEEQEYE EEQPEEEAAE EEEEEEERPK PSRPVVPPLI PPKIPEGERV DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELVALKE RIERRRSERA EQQRFRTEKE RERQAKLAEE KMRKEEEEAK KRAEDDAKKK KVLSNMGAHF GGYLVKAEQK RGKRQTGREM KVRILSERKK PLDIDYMGEE QLREKAQELS DWIHQLESEK FDLMAKLKQQ KYEINVLYNR ISHAQKFRKG AGKGRVGGRW K
Target Information
This gene encodes a protein that is a subunit of troponin, a regulatory complex located on the thin filament of the sarcomere. The complex regulates striated muscle contraction in response to intracellular calcium concentration changes. It consists of three subunits:
- Troponin C: Binds calcium
- Troponin T: Binds tropomyosin
- Troponin I: Inhibitory subunit
This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5 (Amish nemaline myopathy), a neuromuscular disorder characterized by muscle weakness and rod-shaped inclusions in skeletal muscle fibers, typically leading to respiratory failure in infancy. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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