Thermo Fisher Scientific SPAG5 Monoclonal Antibody (OTI5H5), TrueMAB
인체 SPAG5 단백질(1-297 aa)에 특이적인 Mouse IgG1 단일클론 항체입니다. Western blot에 1:500 희석 비율로 검증되었으며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, 안정적 PBS/BSA/glycerol 버퍼 구성으로 연구용에 적합합니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5H5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–297 of human SPAG5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon, and thymus. It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase, playing an essential role in proper spindle formation and mitotic regulation. SPAG5 contributes to sister chromatid cohesion and separation, maintaining chromosome integrity. Structurally, it forms a homodimer with a long stalk and globular head domain. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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