Thermo Fisher Scientific Wilm`s Tumor 1 (WT1) (Wilm`s Tumor and Mesothelial Marker) Monoclonal Antibody (6F-H2)
WT1 단백질을 표적으로 하는 단클론 항체로, 인간·마우스·랫트 시료에 반응. 면역조직화학(IHC) 분석에 적합하며, 고순도 Protein A/G 정제 및 무보존액 PBS 용액 형태. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6F-H2 |
| Immunogen | Recombinant protein corresponding to residues 1–181 of human WT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Wilms Tumor 1 (WT1) gene encodes one of the WPP domain-interacting proteins required for RanGAP nuclear envelope association in root tip cells. Ran GTPase is essential for nucleocytoplasmic transport, spindle formation, and nuclear envelope reassembly. RanGAP establishes a functional RanGTP/RanGDP gradient across the nuclear envelope and associates with its outer surface in metazoan and plant cells. Arabidopsis thaliana RanGAP association requires nucleoporins with coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WT1 and WIT2 form a second family of CC-TMD proteins distinct from WIPs, necessary for RanGAP nuclear envelope association.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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