Thermo Fisher Scientific IGF2R Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are transported within the cell via approximately 300 kDa cation-independent mannose 6-phosphate receptors (CI-MPR). These receptors participate in two interconnected cycles:

1. Biosynthetic cycle: Transport of newly synthesized lysosomal enzymes from the trans-Golgi network to late endosomes or early lysosomes.
2. Endocytic cycle: Transport of extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes.

The entire pool of MPRs cycles between these compartments approximately every 3 hours. The steady-state distribution of MPRs is mainly within late endosomes, fewer in the trans-Golgi network, and about 10% at the cell surface.

In addition to mannose 6-phosphate binding, the MPR also has a binding site for type II insulin-like growth factor (IGF-II) and can bind both ligands simultaneously. A ~240 kDa soluble truncated form representing the extracellular domain of the protein is also found circulating in serum and retains the ability to bind both ligands.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.