Thermo Fisher Scientific TNFR1 Polyclonal Antibody
인간 TNFR1을 인식하는 Rabbit Polyclonal 항체로, WB, ELISA, IP, Functional Assay에 적합합니다. Extracellular region of murine TNF-R I를 면역원으로 사용하였으며, Protein A로 정제된 액상 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| ELISA | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Extracellular region of murine TNF-R I |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087959 |
Product Specific Information
PA1-40293 detects TNF-R I from human samples.
It has been successfully used in ELISA, functional assays, immunoprecipitation, and Western blot applications.
The immunogen is the extracellular region of mouse TNF-R I.
Endotoxin level is <24 EU/mg.
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors.
It mediates cytokine signaling, positive regulation of the NF-κB pathway, angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 can be released into circulation as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12.
Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1 and regulate its signaling.
Mutations in TNFR1 extracellular domains are associated with autosomal dominant periodic fever syndrome due to impaired receptor clearance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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