Thermo Fisher Scientific TNFR1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-40293 detects TNF-R I from human samples.
It has been successfully used in ELISA, functional assays, immunoprecipitation, and Western blot applications.
The immunogen is the extracellular region of mouse TNF-R I.
Endotoxin level is <24 EU/mg.

Target Information

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors.
It mediates cytokine signaling, positive regulation of the NF-κB pathway, angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 can be released into circulation as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12.
Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1 and regulate its signaling.
Mutations in TNFR1 extracellular domains are associated with autosomal dominant periodic fever syndrome due to impaired receptor clearance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.