Thermo Fisher Scientific UK Biobank Axiom Array Kit

Applied Biosystems™ UK Biobank Axiom™ Array Kit

The UK Biobank Axiom Array was designed by and for thought leaders in the human genetics community for high-throughput, high-value genotyping of large sample cohorts. It enables exploration of the genetics of complex diseases and translational research with a single comprehensive, cost-effective solution. The 96-format array plate allows genome-wide genotyping of large sample collections such as those screened at biobanks, genome centers, and core labs.

This array kit includes:

• 1×96-format array plate
• Axiom 2.0 Reagent Kit
• Axiom GeneTitan Consumables Kit

Note: Reagent kits do not include plastic consumables required to run the assay on the Beckman Biomek™ FXP Target Prep Express System. Please contact us for a list of required plastic consumables.

주요 특징

GWAS

• Intelligent marker selection enables imputation of millions of additional SNPs
• Genomic content modules are optimized for specific populations and customizable to any 1000 Genomes population study

Pharmacogenomic Markers

• Markers selected to represent phases of absorption, distribution, metabolism, and excretion (ADME)

Inflammation and HLA

• Contains markers associated with autoimmune and inflammatory responses
• Covers variants in HLA and KIR regions important for immune response

Exome

• Rare, non-synonymous coding SNPs and indels in protein-coding regions
• Majority of variants with minor allele frequency (MAF) <1%
• Includes loss-of-function content and known disease-causing mutations
• Derived from sequencing of 26,000 individuals

eQTLs

• Includes markers associated with RNA expression traits
• Captures unique eQTLs from GTEx, GEUVIDAS, and other discovery projects

Human Disease Coverage

• Alzheimer’s disease (including ApoE)
• Blood phenotypes
• Common cancer variants
• Cardiometabolic traits

Customization

• Pre-designed array can be customized with markers of your choice
• Custom markers may be de novo or selected from the Axiom Genomic Database of genotype-tested markers

사양