Thermo Fisher Scientific GSTM1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: Human liver, Rat liver, Mouse brain
• Predicted reactivity: Mouse (80%), Rat (82%), Bovine (83%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the mu class, which functions in detoxification of electrophilic compounds—including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products—by conjugation with glutathione.
The mu class genes are located on chromosome 1p13.3 and are highly polymorphic, influencing susceptibility to carcinogens and drug responses. Null mutations in this gene class are associated with increased cancer risk due to higher sensitivity to environmental toxins.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.