Thermo Fisher Scientific TAB182 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: A431, H1299
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 inhibits TRF1 binding and induces telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain, suggesting that TAB182 may act as a scaffold to mediate higher-order protein complex formation at telomeres. TAB182 has also been found to localize to the cytoplasmic cortical actin network, suggesting a role in the cytoplasm.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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