Thermo Fisher Scientific Oncomine Myeloid DNA Assay GX v2

Thermo Fisher Scientific Oncomine Myeloid DNA Assay GX v2

The Ion Torrent™ Oncomine™ Myeloid DNA Assay GX v2 is a comprehensive targeted next-generation sequencing (NGS) assay designed for sensitive detection of myeloid disorder-associated DNA mutations in blood and bone marrow samples.
This assay is the DNA component of the Oncomine Myeloid Assay GX v2 (Cat. No. A50694), which includes both DNA and RNA assays.
It is compatible with the Genexus™ Integrated Sequencer, enabling automated library preparation, sequencing, analysis, and reporting in a streamlined sample-to-result workflow. Depending on the workflow, results can be obtained in as little as one day.

주요 특징

• Comprehensive coverage of key DNA mutations associated with myeloid disorders
• Automated sample-to-report workflow on the Genexus sequencer in less than a day
• Sequencing of up to 16 DNA samples on two lanes of a GX5 Chip in a single run
• Less than 15 minutes hands-on time
• Detection of somatic variants down to 5% allele frequency

연구 적용

This assay supports myeloid cancer research, targeting 45 key genes associated with major myeloid disorders, including:

• Acute Myeloid Leukemia (AML)
• Myelodysplastic Syndrome (MDS)
• Myeloproliferative Neoplasms (MPN)
• Chronic Myeloid Leukemia (CML)
• Chronic Myelomonocytic Leukemia (CMML)
• Juvenile Myelomonocytic Leukemia (JMML)

기술적 개요

The multiplex primer design leverages Ion AmpliSeq™ technology, enabling simultaneous processing of multiple samples in one sequencing run.
Sequencing results are automatically analyzed by Genexus™ software using an optimized assay-specific analysis workflow.

키트 구성

• Two pools of Ion AmpliSeq oligonucleotide primers
• Genexus Strips 1 & 2-AS library reagents
• Supports sequencing of up to 32 DNA samples on the Genexus Integrated Sequencer
• One sequencing run uses two lanes on the GX5 Chip (up to 16 samples per run)
• Additional Genexus reagents and supplies must be ordered separately

사양

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