Thermo Fisher Scientific LRP6 Monoclonal Antibody (1A3F5)
LRP6 단백질을 표적하는 고특이성 Mouse IgG1 단일클론 항체. Western blot, Flow cytometry, ELISA에 적합. Wnt/β-catenin 신호전달 연구용으로 활용 가능. Protein G 정제, PBS 버퍼 및 sodium azide 포함, 4°C 또는 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A3F5 |
| Immunogen | Purified recombinant fragment of human LRP6 (aa: extra 1198–1370) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898477 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
LRP6 is essential for the Wnt/β-catenin signaling pathway, acting as a coreceptor with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. Interaction with DKK1 blocks LRP6-mediated Wnt/β-catenin signaling via Kremen proteins-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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