Thermo Fisher Scientific Cerebral Protein 1 Polyclonal Antibody
Human Cerebral Protein 1을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunocytochemistry에 적합. Affinity chromatography로 정제된 고순도 항체이며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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- PA5106639
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RRP8 (Accession O43159), corresponding to amino acid residues F277–R327 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854307 |
Product Specific Information
Antibody detects endogenous levels of total HUCE1.
Target Information
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to intracellular energy status by recruiting histone-modifying enzymes.
Upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation and subsequent dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1, forming silent chromatin in the rDNA locus.
Within the complex, RRP8 binds to H3K9me2 and may act as a methyltransferase, though its substrates remain unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-106639_Cerebral_Protein_1_O43159-1_Rabbit.svg
- PA5-106639_Cerebral_Protein_1_O43159-1_Rabbit_PDP.jpeg
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