Thermo Fisher Scientific GBL Polyclonal Antibody
Thermo Fisher Scientific의 GBL Polyclonal Antibody는 인간 MLST8 단백질을 인식하는 고품질 토끼 IgG 항체입니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, mTOR 신호전달 연구에 유용합니다. 항원 친화 크로마토그래피로 정제된 액상 형태 제품입니다.
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Thermo Fisher Scientific GBL Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human MLST8 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902669 |
Target Information
G-protein beta subunit like (GBL protein) is a novel member of the WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of the mTOR signaling complex (TORC1) and positively regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin, indicating a possible role of LST8 in intracellular events related to insulin-receptor activation, including insulin-stimulated glucose transport and glycogen synthesis. Northern blot analysis detected ubiquitous expression of LST8, with highest expression in brain and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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