Thermo Fisher Scientific WWOX Polyclonal Antibody
Thermo Fisher Scientific의 WWOX Polyclonal Antibody는 인간 WWOX 단백질(364–414번 잔기 영역)을 인식하는 토끼 유래 IgG 항체입니다. Western blot, IHC, IP 등에 사용 가능하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 364–414 of Human WW Domain Containing Oxidoreductase (WWOX) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on sequence identity, this antibody is predicted to react with Orangutan
Target Information
WW domain-containing proteins are found in all eukaryotes and play an important role in regulating various cellular functions such as protein degradation, transcription, and RNA splicing.
This gene encodes a protein with two WW domains and a short-chain dehydrogenase/reductase domain (SRD).
Highest expression is detected in hormonally regulated tissues (testis, ovary, prostate), suggesting a role in steroid metabolism.
The human protein shares >90% identity with the mouse homolog, an essential mediator of TNF-α-induced apoptosis, implying a similar role in apoptosis and tumor suppression.
Alternative splicing generates multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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