Thermo Fisher Scientific Bora Polyclonal Antibody
Thermo Fisher Scientific의 Bora 폴리클로날 항체는 인간 및 생쥐 시료에서 BORA 단백질을 검출합니다. Western blot 및 ICC/IF에 적합하며, 고순도의 Affinity chromatography 정제 항체입니다. 세포주기 조절 연구용으로 최적화된 연구용 시약입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BORA (Accession Q6PGQ7), corresponding to amino acid residues H474–Q524 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899552 |
Product Specific Information
Antibody detects endogenous levels of total BORA.
Target Information
Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly, and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2-dependent manner. Activation of Cdc2 releases Bora into the cytoplasm, where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles identical to those observed when ARK-1 function is blocked, elucidating a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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