Thermo Fisher Scientific ADAM17 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX13535-PEP).
• Expected to cross-react with Chinese Hamster due to sequence homology.
• Detects a band of approximately 125–130 kDa (predicted molecular weight: 95 kDa; when glycosylated, 130 kDa).

Target Information

ADAM17 (Disintegrin and Metalloproteinase Domain-Containing Protein 17)
ADAM17 cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. It is responsible for the proteolytic release of soluble JAM3 from endothelial cell surfaces and several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and amyloid precursor protein.
It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.