Thermo Fisher Scientific Gemin 3 Polyclonal Antibody
Rabbit Polyclonal 항체로 Human Gemin 3 단백질을 인식하며, WB 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 0.65 mg/mL 농도의 액상 형태입니다. 연구용으로만 사용 가능하며, A549, HeLa 등의 세포주에서 양성 대조로 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 319–610 of Human Gemin 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2546674 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HepG2, HCT116
- Predicted reactivity: Bovine (85%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Gemin 3 is a member of the DEAD box protein family characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. These proteins are implicated in various cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
Gemin 3 has ATPase activity and is a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 dysfunction include spinal muscular dystrophy and muscular atrophy.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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