Thermo Fisher Scientific CHRNG Polyclonal Antibody
Rabbit polyclonal antibody targeting CHRNG, reactive with human, mouse, and rat. Validated for Western blot and ELISA. Supplied as a liquid form with 1.61 mg/mL concentration in PBS with glycerol. Suitable for research in neuromuscular receptor studies.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 328–517 of human CHRNG (NP_005190.4) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.61 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901739 |
Product Specific Information
- Positive Samples: Mouse skeletal muscle, Rat skeletal muscle
- Immunogen Sequence:
NVSLRSPHTH SMARGVRKVF LRLLPQLLRM HVRPLAPAAV QDTQSRLQNG SSGWSITTGE EVALCLPRSE LLFQQWQRQG LVAAALEKLE KGPELGLSQF CGSLKQAAPA IQACVEACNL IACARHQQSH FDNGNEEWFL VGRVLDRVCF LAMLSLFICG TAGIFLMAHY NRVPALPFPG DPRPYLPSPD
Target Information
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein composed of two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit.
This gene encodes the gamma subunit, expressed prior to the thirty-third week of gestation in humans. The gamma subunit plays a role in neuromuscular organogenesis and ligand binding, and its disruption prevents proper receptor localization in cell membranes.
Mutations in this gene are associated with Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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