Thermo Fisher Scientific AZIN1 Monoclonal Antibody (OTI3C3), TrueMAB
AZIN1 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot과 IHC(Paraffin)에서 1:2,000 희석 비율로 사용 가능. 인간 유래 항원(aa 260–448)을 면역원으로 제작되었으며, 액상 형태로 1 mg/mL 농도, PBS/BSA/glycerol 완충액에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 260–448 of human AZIN1 produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Antizyme inhibitor (AZIN1) is a protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZIN1 is an enzymatically inactive ODC homolog that counteracts the inhibitory effects of ODC antizymes (OAZ1, OAZ2, OAZ3) by competing for antizyme binding. This prevents antizyme-dependent ODC degradation, releases ODC monomers from inactive complexes, and restores catalytically active ODC homodimer formation, promoting polyamine production.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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