Thermo Fisher Scientific SNCB Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Publications: 없음

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA

Target Information

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases such as Alzheimer’s (AD), Parkinson’s (PD), and breast cancer.

• In AD, a peptide derived from alpha synuclein forms a component of plaque amyloid.
• In PD, alpha synuclein accumulates in Lewy bodies, and its allele is linked to familial PD cases.
• In breast cancer, increased expression of gamma synuclein correlates with disease progression.
  Synucleins appear to play a role in membrane plasticity in the developing song control system of songbirds.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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