Thermo Fisher Scientific ALK Monoclonal Antibody (OTI19H9), TrueMAB
인간 ALK 단백질(aa 1300-1620)을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보관. 뇌 발달 및 종양 관련 ALK 연구용에 적합.
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Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI19H9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a critical role in brain development. Mutations, rearrangements, and amplifications of the ALK gene have been associated with various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. The most common alteration is chromosomal rearrangement, generating a fusion gene between ALK and the nucleophosmin (NPM) gene. The NPM-ALK fusion product is oncogenic. ALK encodes a novel receptor tyrosine kinase with transmembrane and extracellular domains, which are absent in the transforming NPM-ALK fusion protein. ALK shows high sequence similarity to LTK and contributes to neuronal development and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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