Thermo Fisher Scientific IL-1 alpha Monoclonal Antibody (ILA8-H12)

Applications

• ELISA (ELISA): Assay-dependent
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Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

M420A targets IL-1 alpha in ELISA applications and shows reactivity with human samples.
The immunogen is recombinant human IL-1 alpha.
M420A detects IL-1 alpha, which has a predicted molecular weight of approximately 18 kDa.
This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration ≤10 EU/mg.

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, which are shared with IL-1 beta.
Located on chromosome 2q13, IL-1 alpha plays a key role in innate host defense by triggering the production of other proinflammatory cytokines and initiating acute-phase responses.
Its activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), which blocks receptor binding through competitive inhibition.
IL-1 alpha regulates NF-kappaB and MAPK pathways, stimulates IL6 and COX-2 expression, and enhances nitric oxide (NO) production.
Elevated IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.