Thermo Fisher Scientific PCNA-proliferation Marker Polyclonal Antibody
PCNA 단백질을 표적하는 Rabbit Polyclonal 항체로, 세포 증식 마커 연구에 적합합니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, Human, Mouse, Rat에 반응합니다. Protein A 정제, 1 mg/mL 농도의 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PCNA, amino acids 151–261 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PCNA (Proliferating Cell Nuclear Antigen) is essential for DNA replication and plays a key role in DNA excision and mismatch repair. It interacts with CDK inhibitor p21, endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA serves as a marker for proliferating cells and is often used to assess tumor proliferation status. It is primarily localized in the nucleus and functions as a cofactor for DNA polymerase delta, forming a homotrimer that enhances DNA synthesis during replication. Upon DNA damage, PCNA undergoes ubiquitination and participates in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been identified, with pseudogenes located on chromosome 4 and the X chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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