Thermo Fisher Scientific Human Mesothelin Recombinant Protein, PeproTech
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
100-63-1MG | - | Thermo Fisher Scientific 100-63-1MG Human Mesothelin Recombinant Protein, PeproTech 1 mg pk | 재고문의 | pk | 2,476,000원 | - | 2,723,600원 | |
100-63-500UG | - | Thermo Fisher Scientific 100-63-500UG Human Mesothelin Recombinant Protein, PeproTech 500 ug pk | 재고문의 | pk | 1,545,000원 | - | 1,699,500원 | |
100-63-250UG | - | Thermo Fisher Scientific 100-63-250UG Human Mesothelin Recombinant Protein, PeproTech 250 ug pk | 재고문의 | pk | 965,000원 | - | 1,061,500원 | |
100-63-100UG | - | Thermo Fisher Scientific 100-63-100UG Human Mesothelin Recombinant Protein, PeproTech 100 ug pk | 재고문의 | pk | 618,000원 | - | 679,800원 | |
100-63-50UG | - | Thermo Fisher Scientific 100-63-50UG Human Mesothelin Recombinant Protein, PeproTech 50 ug pk | 재고문의 | pk | 311,000원 | - | 342,100원 | |
100-63-10UG | - | Thermo Fisher Scientific 100-63-10UG Human Mesothelin Recombinant Protein, PeproTech 10 ug pk | 재고문의 | pk | 139,000원 | - | 152,900원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
ELISA (ELISA)
Assay-dependent
Functional Assay (Functional)
Assay-dependent
Product Specifications
Species
Human
Expression System
CHO cells
Amino acid sequence
EVEKTACPSG KKAREIDESL IFYKKWELEA CVDAALLATQ MDRVNAIPFT YEQLDVLKHK LDELYPQGYP ESVIQHLGYL FLKMSPEDIR KWNVTSLETL KALLEVNKGH EMSPQVATLI DRFVKGRGQL DKDTLDTLTA FYPGYLCSLS PEELSSVPPS SIWAVRPQDL DTCDPRQLDV LYPKARLAFQ NMNGSEYFVK IQSFLGGAPT EDLKALSQQN VSMDLATFMK LRTDAVLPLT VAEVQKLLGP HVEGLKAEER HRPVRDWILR QRQDDLDTLG LGLQGGIPNG YLVLDLSMQE ALSGTPCLLG PGPVLTVLAL LLASTLA
Molecular weight
36.4 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to bind immobilized recombinant CA125/MUC16 in a functional ELISA.
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
PeproTech`s CHO cell-derived Recombinant Human Mesothelin is a glycoprotein containing 327 amino acid residues, and has a calculated molecular weight of approximately 36.4 kDa. As a result of glycosylation, Recombinant Human Mesothelin migrates with an apparent molecular mass of approximately 40-45 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
Originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas, Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by cells of the mesothelium. Although Mesothelin is expressed at restricted levels by normal mesothelial cells of the pleural,pericardial, and peritoneal membranes, aberrant expression has been documented in the aforementioned cancers, as well as in endometriod uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix. Proteolytic cleavage of Mesothelin yields a soluble, polypeptide fragment designated megakaryocyte potentiating factor (MPF) based on its ability to stimulate megakaryocyte colony-forming activity of murine interleukin-3 in murine bone marrow cell cultures. Originally isolated from the HPC-Y5 pancreatic cell line, MPF has been suggested to play a role in the proliferation and differentiation of megakaryoctyes, and the regulation of resultant platelet production. While the biological functions of both Mesothelin and MPF remain speculative, high-levels of expression in cancerous tissues compared to limited distribution in normal tissues strongly suggests their involvement in tumorigenesis. Both have been demonstrated to promote tumor cell proliferation, migration,anchorage-independent growth, and tumor progression; demonstrating their involvement in heterotypic cell adhesion and the metastatic spread of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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